Therapeutic Dosing & Safety Guide

Settle & Soothe | Histamine & Mast Cell Support

Formula Overview

  • Ingredients: Organic Chinese Skullcap Root, Organic Nettle Leaf, Organic Albizia Bark Extract, Organic Holy Basil Leaf, Organic Perilla Leaf Extract, Organic Calendula Flower, Organic Goldenrod Leaf & Stem, Organic Giloy Leaf & Stem
  • Strength: 1:1.25 herb ratio (high potency)
  • Double Extracted 
  • High-potency whole-herb blend designed for histamine modulation, MCAS support, sinus health, skin balance, and food-triggered histamine reactions.
  • Formulated for sensitive systems requiring a stabilizing, non-stimulating, anti-histamine–like herbal synergy.

Adult Dosing Charts

These recommendations represent standard therapeutic durations. Depending on individual response, sensitivity, and underlying conditions, some individuals may require longer support or higher-frequency dosing. Consult a qualified healthcare practitioner for personalized dosing.
Begin with the lower end of the range and increase gradually as tolerated.

Maintenance & Prevention
Goal
Dose
Frequency
Duration
Daily histamine balance
1 mL
Daily
Long-term
Seasonal priming (2 weeks before allergy season)
1 mL
Daily
2 weeks pre-season
Skin & sinus support
1 mL
Daily
Ongoing
Food-trigger anticipation (pre-meal)
1 mL
Before meals
As needed
Acute Histamine Reactions & Flares
Condition
Dose
Frequency
Duration
Acute histamine flare (skin/sinus)
2 mL
2–3× daily
3–7 days
Seasonal allergy flare
2 mL
2× daily
5–10 days
Food-triggered histamine response
2 mL
Once at onset
As needed
Dermatographia flare
2 mL
1–2× daily
3–7 days
Post-viral histamine spike
2 mL
2× daily
5–10 days
Chronic MCAS / Histamine Intolerance
Condition
Dose
Frequency
Duration
Chronic MCAS support
1–2 mL
Daily
8–12 weeks
Chronic sinus histamine issues
1–2 mL
Daily
6–12 weeks
Chronic skin histamine (eczema, hives)
1–2 mL
Daily
8–12+ weeks
Food-triggered intolerance (ongoing)
1 mL
Daily
Long-term

Pediatric Dosage

  • Avoid under age 1.
  • Ages 1–3: use conservative dosing; start very low and increase slowly.
  • This blend is designed for sensitive systems but is potent; monitor response carefully.
Age
Dose
Frequency
Use cases
1–2 yrs
0.25 mL (8 drops)
1× daily
Mild allergies, skin histamine, sinus irritation
3–5 yrs
0.5 mL
1–2× daily
Seasonal support, food-triggered histamine
6–9 yrs
0.75–1 mL
1–2× daily
MCAS tendencies, chronic sinus issues
10–12 yrs
1–1.5 mL
1–2× daily
Skin flares, chronic histamine patterns

Safety & Interactions

Concern
Guidance
Pregnancy
Not recommended due to mast-cell–active botanicals.
Breastfeeding
Generally compatible in moderate doses; reduce if infant shows sensitivity.
Autoimmune medications
Herbs may modulate immune activity; consult practitioner.

Best Time-of-Day Usage

Goal
Ideal timing
Nighttime itching or histamine flares
Evening
Post-viral histamine spikes
Morning
Skin histamine control
Morning + afternoon
Food-trigger prevention
15 minutes before meals
Seasonal allergies
Morning (daily)
Disclaimer

This guide provides general therapeutic ranges and does not replace licensed medical care. Consult a healthcare practitioner if pregnant, breastfeeding, taking medications, or managing chronic MCAS or histamine-related conditions.
Suggested use may vary depending on individual needs and goals. Some blends are used short term for acute support, while others may be taken over a longer period for chronic or ongoing wellness support, or at a lower maintenance dose once balance is achieved.
We recommend starting with the suggested dosage and reassessing after the initial support period to determine whether continued use is needed, whether the dosage should be adjusted, or whether it’s appropriate to take a break. Everyone’s body and situation are unique, and needs may change over time.
For ongoing or long-term use, or if symptoms persist, we encourage checking in with your healthcare provider or qualified practitioner to ensure the blend continues to be the right fit for where you are currently at.
As always, listen to your body, start low and slow when introducing any new product, and adjust as needed with professional guidance.